FIG 9.

Oncolytic effect of an LP avian influenza A virus in an orthotopic SCID mouse model of pancreatic ductal adenocarcinoma. BxPC-3 cells (5 × 10⁶) in a volume of 100 μl were subcutaneously implanted in the right flanks of 6-week-old female SCID mice. At 8 days postimplantation, palpable tumors became established, and mice were randomly divided in two groups (n = 6 each) receiving either four intratumoral injections of 2.4 × 10⁴ PFU of LP H7N3 virus (circles) between day 8 and day 15 or four injections of PBS (squares). Caliper measurements of tumor dimensions were taken on the indicated days after BxPC-3 implantation for calculation of tumor volumes. Data shown represent mean tumor volumes plus standard errors of the means.