TABLE 6.
Serum antibody titers of ferrets infected with avian H7N9 or H7N7 determined by ELISA, virus neutralization assay, and HI assay
| Virus and ferret no. (dpi) | ELISA |
Neutralization of: |
HI of: |
|||
|---|---|---|---|---|---|---|
| Anti-NPa | Anti-H7b | H7N9 | H7N7 | H7N9 | H7N7 | |
| A/Anhui/1/13 (H7N9) | ||||||
| F1 (17) | 7.5 | 24.1 | 202 | 101 | 256 | 8 |
| F2 (17) | 12.4 | 40.5 | 403 | 25.2 | 256 | 16 |
| F3 (4) | 96.0 | 102.7 | <8 | <8 | 8 | <2 |
| F4 (4) | 83.8 | 96.4 | <8 | <8 | NDd | ND |
| F5 (4) | 80.8 | 97.6 | <8 | <8 | ND | ND |
| F6 (4) | 62.7 | 97.0 | <8 | <8 | ND | ND |
| A/turkey/Germany/AR534/13 (H7N7) | ||||||
| F7 (17) | 13.6 | 33.8 | 40 | 33.8 | 32 | 4 |
| F8 (17) | 16.0 | 38.3 | 40 | 38.3 | 64 | 16 |
| F9 (4) | 109.6 | 98.0 | <8 | <8 | 8 | <2 |
| F10 (4) | 84.6 | 99.8 | <8 | <8 | ND | ND |
| F11 (4) | 73.7 | 96.1 | <8 | <8 | ND | ND |
| F12 (4) | 73.9 | 103.0 | <8 | <8 | ND | ND |
| Controlc | ||||||
| F13 (17) | 103.4 | 97.2 | <8 | <8 | <2 | <2 |
| F14 (4) | 76.7 | 95.4 | <8 | <8 | ND | ND |
a
Anti-NP ELISA: positive (bold), <55; negative, >65; questionable: 55 to 65.
b
Anti-H7 ELISA: positive (bold), <50; negative, >60; questionable: 50 to 60.
c
PBS-inoculated animals.
d
ND, not determined.