TABLE 2.
Virus strain | Animal ID | Clinical symptom(s)b |
---|---|---|
VN3028IIcl3 | 1 | Decreased activity and mild depression on day 2 |
2 | – | |
3 | Mild coughing on day 10 | |
VN30259 | 4 | – |
5 | Mild huddling on day 5; nasal discharge on days 5 and 6 | |
6 | – | |
VN3040 | 7 | Decreased activity on days 2, 3, 4, 5, 7, and 8; mild depression on days 3, 5, 7, and 8; mild coughing on day 8 |
8 | Decreased activity on days 2 and 5; mild depression on day 5 | |
9 | Decreased activity and lying down on day 8; dying on day 9 | |
VN3062 | 10 | – |
11 | Mild huddling on day 6 | |
12 | Piloerection of body hair on days 1, 2, 4, 6, and 7 | |
VN30408cl7 | 13 | Nasal discharge on day 5 |
14 | – | |
15 | – | |
VN30850 | 16 | – |
17 | Mild coughing on days 2 and 3; mild huddling on day 7 | |
18 | Piloerection of body hair on day 0; mild huddling on days 1, 2, and 3 |
Cynomolgus macaques were inoculated with 107.8 PFU thorough multiple routes and monitored twice daily throughout the study for each clinical parameter, i.e., posture, respiration, recumbency, attitude, and skin condition.
–, No clinical symptom observed.