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Airway hyperresponsiveness during secondary CA04 reinfection. (A) Newtonian resistance (RN) and (B) tissue damping (G) in response to increasing doses of methacholine were measured on day 6 post-CAO4 challenge using a mechanical animal ventilator. (C) Weight loss was also determined on day 6 post-CA04 challenge. The data represent the means ± SD of results for 3 to 8 mice/group from two independent experiments. *, P < 0.05.
