FIG 7.

Depletion of either CD4⁺ or CD8⁺ T cells does not diminish cross-protective immunity. T cells were depleted by i.p. injection of either GK1.5 MAb (for CD4⁺ T-cell depletion) or 2.43 MAb (for CD8⁺ T-cell depletion). Control mice were treated with rat IgG. Successful T-cell depletion was confirmed by flow cytometry using fluorescent conjugated anti-CD4 (clone RM4.4) and anti-CD8 (clone 53-6.72) MAbs. Control and T-cell-depleted mice were infected with CA04 virus and monitored for survival (4 to 7 mice/group). N.S., P > 0.05.