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. 2014 Aug;88(16):9141–9152. doi: 10.1128/JVI.00619-14

TABLE 1.

Functional comparison of Vpr mutantsa

Vpr protein Cell cycle arrest LTR transactivation Reduction of whole-cell ubiquitination
VprB + + +
VprC + + +
L22A + ++ −
L64A − − −
L64P − − −
L67A + − −
L68A + − −
R62P − ND −
R80A − − +
a

wt Vpr and point mutants are compared for their abilities to cause G2/M arrest, LTR transactivation, and reduction in whole-cell ubiquitination (37, 41–44). +, shows activity; ++, shows high level of activity; −, shows no activity; ND, not determined.