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Predicted E1-E2 WEEV trimers. (A to C) Mapping of all mutations on WEEV BFS932 surface compared to all WEEV strains. (A) Top view; (B) side view; (C) bottom view. (D to F) Mapping of all mutations on the WEEV BFS932 surface compared to WEEV Imperial181. (D) Top view; (E) side view; (F) bottom view. All mutations in the E1 protein are shown in yellow, and those from the E2 protein are shown in red. Amino acids 374 in E1 protein (magenta) and 23 in E2 protein (green) also are indicated.
