TABLE 1.
Cytokine levels in the DLNs of neonatal mice at 12 hpi
| Cytokine | Mean cytokine level (pg/ml ± SEM) in mice immunized with the following: |
Fold increase over iFlua | ||
|---|---|---|---|---|
| PBS | iFlu | iFlu + GVI3000 | ||
| G-CSF | 28.84 ± 1.55 | 29.92 ± 1.92 | 173.23 ± 7.66 | 5.79 |
| GM-CSF | 6.90 ± 0.57 | 11.21 ± 3.72 | 36.02 ± 1.64 | 3.21 |
| IFN-γ | 0.60 ± 0.00 | 0.60 ± 0.00 | 917.16 ± 102.16 | 1,528.60* |
| IL-1β | 4.10 ± 0.51 | 11.99 ± 1.72 | 25.78 ± 0.96 | 2.15 |
| IL-2 | 28.11 ± 1.71 | 30.44 ± 0.47 | 33.25 ± 1.18 | 1.09 |
| IL-4 | 0.26 ± 0.06 | 0.41 ± 0.10 | 1.54 ± 0.13 | 3.76 |
| IL-5 | 1.02 ± 0.52 | 4.94 ± 1.83 | 18.37 ± 0.91 | 3.72 |
| IL-6 | 32.21 ± 11.14 | 51.72 ± 2.81 | 148.99 ± 4.67 | 2.88 |
| IL-10 | 7.63 ± 4.20 | 9.60 ± 3.15 | 20.48 ± 2.20 | 2.13 |
| IL-12p70 | 2.40 ± 0.00 | 2.40 ± 0.00 | 2.40 ± 0.00 | 1.00 |
| IP-10 | 79.55 ± 7.78 | 99.66 ± 11.41 | 2731.05 ± 69.26 | 27.40* |
| MCP-1 | 8.07 ± 2.87 | 11.02 ± 3.55 | 230.22 ± 18.52 | 20.89* |
| MIG | 122.99 ± 30.75 | 73.29 ± 5.66 | 7338.89 ± 227.30 | 100.13* |
| MIP-1α | 11.77 ± 0.94 | 18.13 ± 0.98 | 55.51 ± 4.89 | 3.06 |
| MIP-1β | 7.02 ± 0.95 | 8.63 ± 0.90 | 134.45 ± 12.81 | 15.58 |
| MIP-2 | 75.43 ± 1.71 | 70.57 ± 2.70 | 96.66 ± 3.63 | 1.37 |
| RANTES | 7.02 ± 0.93 | 5.63 ± 1.05 | 39.78 ± 3.14 | 7.07 |
| TNF-α | 1.60 ± 0.00 | 1.60 ± 0.00 | 5.24 ± 0.66 | 3.28 |
a
Values that are statistically significantly different (P < 0.05) from the value for the group immunized with iFlu are indicated by an asterisk.