TABLE 5.
Amino acid differences between viruses NY99-4132 and Koutango Dak ArD 5443
| Gene and aa position in polyprotein (corresponding protein position) | NY99 4132 virusa amino acid | Koutango Dak ArD 5443 virusb amino acid | No. of substitutions in each gene (no. of nonconservative changes), % total changes |
|---|---|---|---|
| C | 13 (6), 46 | ||
| 11 (11) | S | N | |
| 25 (25) | L | P | |
| 63 (63) | R | K | |
| 71 (71) | G | K | |
| 100 (100) | S | T | |
| 108 (108) | K | T | |
| 111 (111) | I | L | |
| 113 (113) | V | C | |
| 114 (114) | M | I | |
| 115 (115) | I | L | |
| 117 (117) | L | M | |
| 118 (118) | I | L | |
| 120 (120) | S | T | |
| prM | 27 (15), 56 | ||
| 126 (3) | L | F | |
| 128 (5) | N | S | |
| 132 (9) | K | R | |
| 141 (18) | D | E | |
| 143 (20) | T | A | |
| 147 (24) | T | S | |
| 150 (27) | T | I | |
| 152 (29) | A | S | |
| 156 (33) | L | Q | |
| 158 (35) | I | T | |
| 162 (39) | M | I | |
| 181 (58) | A | P | |
| 193 (70) | T | D | |
| 195 (72) | S | M | |
| 197 (74) | V | I | |
| 205 (82) | T | I | |
| 206 (83) | K | R | |
| 207 (84) | T | G | |
| 208 (85) | R | K | |
| 209 (86) | H | N | |
| 210 (87) | S | P | |
| 235 (112) | M | L | |
| 264 (141) | I | L | |
| 270 (147) | S | G | |
| 273 (150) | M | T | |
| 279 (156) | V | A | |
| 280 (157) | V | I | |
| E | 63 (33), 52 | ||
| 313 (23) | L | I | |
| 321 (31) | V | I | |
| 333 (43) | V | I | |
| 336 (46) | M | L | |
| 337 (47) | N | S | |
| 339 (49) | E | S | |
| 341 (51) | A | T | |
| 354 (64) | T | A | |
| 355 (65) | V | I | |
| 358 (68) | L | P | |
| 378 (88) | P | S | |
| 380 (90) | F | Y | |
| 383 (93) | R | K | |
| 410 (120) | A | T | |
| 414 (124) | K | Q | |
| 416 (126) | I | V | |
| 418 (128) | R | K | |
| 419 (129) | T | I | |
| 421 (131) | L | Q | |
| 430 (140) | A | S | |
| 439 (149) | V | L | |
| 445 (155) | Y | F | |
| 446 (156) | S | P | |
| 449 (159) | V | R | |
| 450 (160) | G | T | |
| 456 (166) | R | T | |
| 457 (167) | F | I | |
| 459 (169) | I | V | |
| 460 (170) | T | S | |
| 462 (172) | A | S | |
| 466 (176) | Y | S | |
| 472 (182) | E | D | |
| 478 (188) | V | I | |
| 486 (196) | I | V | |
| 489 (199) | N | S | |
| 498 (208) | T | S | |
| 500 (210) | T | S | |
| 516 (226) | S | A | |
| 518 (228) | A | P | |
| 520 (230) | S | A | |
| 521 (231) | T | S | |
| 522 (232) | V | T | |
| 530 (240) | M | L | |
| 543 (253) | I | V | |
| 566 (276) | S | N | |
| 568 (278) | T | N | |
| 600 (310) | K | Q | |
| 602 (312) | L | H | |
| 604 (314) | T | H | |
| 618 (328) | Q | K | |
| 651 (361) | F | Y | |
| 653 (363) | S | A | |
| 654 (364) | V | S | |
| 655 (365) | A | S | |
| 656 (366) | T | A | |
| 660 (370) | K | I | |
| 680 (390) | E | D | |
| 700 (410) | T | A | |
| 702 (412) | L | V | |
| 724 (434) | V | I | |
| 728 (438) | V | L | |
| 757 (467) | A | V | |
| 769 (479) | R | K | |
| NS1 | 43 (21), 49 | ||
| 800 (9) | S | T | |
| 820 (29) | M | V | |
| 825 (34) | Y | F | |
| 826 (35) | Y | H | |
| 837 (46) | I | V | |
| 842 (51) | K | A | |
| 845 (54) | V | I | |
| 848 (57) | L | I | |
| 861 (70) | A | S | |
| 862 (71) | V | I | |
| 884 (93) | Q | H | |
| 896 (105) | T | P | |
| 897 (106) | A | S | |
| 904 (113) | I | M | |
| 914 (123) | L | I | |
| 937 (146) | Q | S | |
| 938 (147) | N | R | |
| 944 (153) | L | M | |
| 960 (169) | L | M | |
| 965 (174) | S | I | |
| 983 (192) | L | Q | |
| 985 (194) | I | V | |
| 999 (205) | R | G | |
| 1010 (219) | E | D | |
| 1025 (234) | D | E | |
| 1026 (235) | G | S | |
| 1027 (236) | I | V | |
| 1031 (240) | D | E | |
| 1036 (245) | V | I | |
| 1042 (251) | R | K | |
| 1052 (261) | K | M | |
| 1066 (275) | I | L | |
| 1075 (284) | T | K | |
| 1078 (287) | L | V | |
| 1080 (289) | E | A | |
| 1081 (290) | S | L | |
| 1084 (293) | H | R | |
| 1106 (315) | S | T | |
| 1117 (326) | D | E | |
| 1129 (338) | Q | T | |
| 1134 (343) | K | R | |
| 1140 (349) | Q | K | |
| 1142 (351) | N | E | |
| NS2A | 32 (14), 44 | ||
| 1177 (34) | M | V | |
| 1181 (38) | L | M | |
| 1182 (39) | I | V | |
| 1186 (43) | V | T | |
| 1197 (54) | V | L | |
| 1198 (55) | L | V | |
| 1201 (58) | V | I | |
| 1211 (68) | S | A | |
| 1239 (96) | K | R | |
| 1240 (97) | A | S | |
| 1255 (112) | V | A | |
| 1262 (119) | H | Q | |
| 1264 (121) | A | C | |
| 1265 (122) | R | H | |
| 1266 (123) | Q | H | |
| 1267 (124) | I | L | |
| 1268 (125) | L | I | |
| 1269 (126) | L | T | |
| 1290 (147) | T | S | |
| 1301 (158) | L | M | |
| 1310 (167) | R | K | |
| 1311 (168) | R | C | |
| 1324 (181) | V | I | |
| 1326 (183) | I | V | |
| 1330 (187) | I | L | |
| 1333 (190) | K | R | |
| 1335 (192) | S | N | |
| 1336 (193) | A | S | |
| 1342 (199) | G | S | |
| 1355 (212) | L | A | |
| 1359 (216) | M | L | |
| 1366 (223) | I | L | |
| NS2B | 9 (2), 22 | ||
| 1400 (26) | I | V | |
| 1433 (59) | D | N | |
| 1435 (61) | S | T | |
| 1438 (64) | S | N | |
| 1449 (75) | V | I | |
| 1459 (85) | F | Y | |
| 1473 (99) | M | I | |
| 1481 (107) | I | V | |
| 1494 (120) | V | I | |
| NS3 | 48 (19), 40 | ||
| 1538 (33) | S | N | |
| 1592 (87) | H | Q | |
| 1597 (92) | Q | V | |
| 1614 (109) | V | I | |
| 1615 (110) | R | Q | |
| 1620 (115) | V | I | |
| 1660 (155) | I | V | |
| 1667 (162) | I | V | |
| 1677 (172) | D | E | |
| 1680 (175) | I | A | |
| 1682 (177) | A | V | |
| 1708 (203) | R | K | |
| 1720 (215) | R | K | |
| 1725 (220) | A | V | |
| 1754 (249) | P | T | |
| 1758 (253) | N | S | |
| 1772 (267) | T | H | |
| 1778 (273) | P | S | |
| 1811 (306) | E | S | |
| 1827 (322) | T | S | |
| 1829 (324) | D | E | |
| 1836 (331) | S | A | |
| 1841 (336) | L | I | |
| 1852 (347) | S | T | |
| 1861 (356) | T | V | |
| 1863 (358) | K | R | |
| 1873 (368) | M | L | |
| 1887 (382) | K | R | |
| 1889 (384) | V | I | |
| 1940 (435) | I | L | |
| 1951 (446) | E | D | |
| 1954 (449) | A | S | |
| 1955 (450) | V | I | |
| 1972 (467) | S | A | |
| 1991 (486) | F | S | |
| 2011 (506) | I | V | |
| 2014 (509) | F | L | |
| 2016 (511) | Q | E | |
| 2023 (518) | Y | F | |
| 2024 (519) | T | S | |
| 2045 (540) | T | A | |
| 2053 (548) | A | S | |
| 2061 (556) | V | I | |
| 2067 (562) | R | K | |
| 2074 (569) | R | K | |
| 2075 (570) | T | V | |
| 2078 (573) | I | V | |
| 2102 (597) | I | T | |
| NS4A | 22 (11), 50 | ||
| 2127 (3) | I | V | |
| 2129 (5) | L | V | |
| 2135 (11) | K | R | |
| 2142 (18) | G | T | |
| 2145 (21) | W | M | |
| 2148 (24) | L | F | |
| 2178 (54) | I | V | |
| 2179 (55) | A | V | |
| 2186 (62) | V | I | |
| 2188 (64) | T | S | |
| 2189 (65) | M | L | |
| 2193 (69) | F | L | |
| 2209 (85) | A | V | |
| 2213 (89) | V | T | |
| 2221 (97) | A | S | |
| 2222 (98) | E | D | |
| 2224 (100) | P | S | |
| 2234 (110) | L | M | |
| 2259 (135) | V | I | |
| 2264 (140) | V | I | |
| 2265 (141) | M | L | |
| 2266 (142) | T | A | |
| NS4B | 28 (13), 46 | ||
| 2276 (3) | M | L | |
| 2281 (8) | K | R | |
| 2284 (11) | S | N | |
| 2288 (15) | S | N | |
| 2291 (18) | G | A | |
| 2293 (20) | R | G | |
| 2294 (21) | I | V | |
| 2296 (23) | V | K | |
| 2300 (27) | F | L | |
| 2301 (28) | S | N | |
| 2302 (29) | M | I | |
| 2314 (41) | A | S | |
| 2321 (48) | T | S | |
| 2369 (96) | L | F | |
| 2373 (100) | A | V | |
| 2387 (114) | A | T | |
| 2427 (154) | I | M | |
| 2449 (176) | I | V | |
| 2450 (177) | M | I | |
| 2456 (183) | L | I | |
| 2459 (186) | V | L | |
| 2460 (187) | V | I | |
| 2466 (193) | K | R | |
| 2476 (203) | T | S | |
| 2477 (204) | A | S | |
| 2513 (240) | I | V | |
| 2518 (245) | I | V | |
| 2521 (248) | M | L | |
| NS5 | 86 (39), 45 | ||
| 2539 (11) | V | F | |
| 2543 (15) | R | K | |
| 2548 (21) | K | R | |
| 2553 (25) | T | N | |
| 2561 (33) | I | V | |
| 2565 (38) | S | L | |
| 2573 (45) | K | R | |
| 2602 (74) | V | I | |
| 2657 (129) | G | K | |
| 2663 (135) | R | K | |
| 2667 (139) | C | S | |
| 2682 (154) | A | P | |
| 2684 (156) | V | I | |
| 2690 (162) | I | L | |
| 2691 (163) | R | K | |
| 2705 (177) | R | K | |
| 2709 (181) | V | I | |
| 2722 (194) | K | R | |
| 2725 (197) | L | V | |
| 2757 (229) | V | I | |
| 2760 (232) | S | A | |
| 2762 (234) | N | S | |
| 2775 (247) | R | K | |
| 2802 (274) | S | N | |
| 2805 (277) | S | G | |
| 2809 (281) | N | R | |
| 2815 (287) | R | K | |
| 2816 (288) | R | Q | |
| 2824 (296) | H | L | |
| 2826 (298) | E | P | |
| 2840 (312) | D | E | |
| 2901 (373) | K | R | |
| 2902 (374) | Y | K | |
| 2905 (377) | N | D | |
| 2909 (381) | N | D | |
| 2913 (385) | A | N | |
| 2916 (388) | A | K | |
| 2920 (392) | R | K | |
| 2925 (397) | S | T | |
| 2931 (403) | R | S | |
| 2950 (422) | R | S | |
| 2966 (438) | D | E | |
| 2967 (439) | E | Q | |
| 3048 (520) | I | V | |
| 3054 (526) | T | G | |
| 3055 (527) | R | K | |
| 3074 (546) | R | K | |
| 3081 (553) | A | G | |
| 3085 (557) | E | R | |
| 3086 (558) | L | F | |
| 3088 (560) | D | E | |
| 3093 (565) | R | L | |
| 3116 (588) | D | N | |
| 3118 (590) | R | K | |
| 3160 (632) | I | V | |
| 3163 (635) | D | E | |
| 3169 (641) | T | G | |
| 3173 (645) | G | E | |
| 3174 (646) | P | A | |
| 3175 (647) | K | R | |
| 3177 (649) | R | K | |
| 3178 (650) | T | S | |
| 3181 (653) | F | S | |
| 3231 (703) | T | V | |
| 3234 (706) | Y | H | |
| 3238 (710) | Q | Y | |
| 3247 (719) | T | A | |
| 3268 (740) | V | I | |
| 3282 (754) | R | K | |
| 3283 (755) | D | E | |
| 3300 (772) | F | L | |
| 3318 (790) | V | M | |
| 3333 (805) | G | K | |
| 3344 (816) | E | A | |
| 3353 (825) | E | D | |
| 3365 (837) | K | R | |
| 3388 (860) | A | P | |
| 3397 (869) | Q | H | |
| 3398 (870) | V | A | |
| 3413 (885) | V | I | |
| 3418 (890) | S | T | |
| 3420 (892) | K | R | |
| 3425 (897) | T | A | |
| 3426 (898) | T | S | |
| 3427 (899) | L | V | |
| 3441 (903) | T | S | |
| Total | 371 (173), 47 |