TABLE 4.
Airborne transmission of reassortant SH7 viruses with site-directed mutations in HA or PA gene
| Virus and group | Virus shedding on daya: |
Seroconversionb (HI titer) | |||
|---|---|---|---|---|---|
| 3 | 5 | 7 | 9 | ||
| 7HAL226Qc | |||||
| Inoculated | 1/3 | 3/3 | 3/3 | 0/3 | 3/3 (1,280, 1,280, 1,280) |
| Exposed | 0/3 | 3/3 | 3/3 | 1/3 | 3/3 (320, 320, 640) |
| 7HAK363R | |||||
| Inoculated | 2/3 | 3/3 | 3/3 | 0/3 | 3/3 (1,280, 1,280, 1,280) |
| Exposed | 0/3 | 0/3 | 1/3 | 0/3 | 0/3 (<10, <10, <10) |
| 7HAV451M | |||||
| Inoculated | 2/3 | 3/3 | 3/3 | 0/3 | 3/3 (1,280, 1,280, 1,280) |
| Exposed | 0/3 | 0/3 | 2/3 | 0/3 | 2/3 (<10, 20, 40) |
| 7PAI63V | |||||
| Inoculated | 3/3 | 3/3 | 2/3 | 0/3 | 3/3(320, 640, 1,280) |
| Exposed | 1/3 | 2/3 | 3/3 | 2/3 | 3/3 (80, 160, 640) |
| 7PAD216N | |||||
| Inoculated | 3/3 | 3/3 | 2/3 | 0/3 | 3/3 (320, 640, 640) |
| Exposed | 0/3 | 2/3 | 3/3 | 2/3 | 3/3 (40, 160, 160) |
| 7PAL672F | |||||
| Inoculated | 1/3 | 3/3 | 3/3 | 0/3 | 3/3 (320, 640, 1,280) |
| Exposed | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 (<10, <10, <10) |
| 7PAI683L | |||||
| Inoculated | 1/3 | 3/3 | 3/3 | 0/3 | 3/3 (640, 640, 1,280) |
| Exposed | 0/3 | 0/3 | 1/3 | 1/3 | 2/3 (<10, 20, 40) |
a
The number of days after chickens were inoculated/exposed. Data are numbers of chickens shedding virus/total number of chickens.
b
HI antibody titers of chickens on day 21 postinoculation/postexposure.
c
The amino acids are represented by individual letter abbreviations. L, leucine; Q, glutamine; K, lysine; R, arginine; V, valine; M, methionine; I, isoleucine; D, aspartic acid, N, asparaginate; F, phenylalanine.