TABLE 2.
Number of I-Ak+ peptides (of a total of 14 I-Ak+ peptides) whose responses were differentially affected by disulfide deletiona
| Response | gp120dss298 | gp120dss378 | gp120dss385 |
|---|---|---|---|
| Secretion of: | |||
| IL-4 | 12 | 7 | 8 |
| IL-2 | 10 | 7 | 11 |
| IL-10 | 9 | 6 | 11 |
| IL-6 | 8 | 7 | 8 |
| IL-13 | 7 | 6 | 8 |
| TNF-α | 7 | 4 | 10 |
| IFN-γ | 8 | 5 | 7 |
| IL-5 | 7 | 7 | 4 |
| Cell proliferation | 10 | 6 | 8 |
Numbers in boldface indicate significant association between differential effect and I-Ak+ status: 12 peptides, P < 0.0001; 11 peptides, P < 0.0001; 10 peptides, P = 0.0014; 9 peptides, P = 0.014.