TABLE 2.

Bronchoalveolar lavage fluid cytokine and chemokine responses to influenza were significantly altered in A₁-KO mice

Day p.i.a	Miceb	No. of mice	Mean concn (pg/ml) ± SEMc
			IFN-α	IFN-γ	IL-6	IL-10	IP-10	KC	MCP-1	RANTES
0	WT	5	11 ± 1	<10	<10	17 ± 3	<10	<10	20 ± 1	<10
	A1-KO	4	<10	<10	14 ± 2	25 ± 7	<10	15 ± 2	34 ± 4	<10
2	WT	8	454 ± 45	18 ± 3	560 ± 61	55 ± 8	444 ± 20	309 ± 52	824 ± 85	155 ± 23
	A1-KO	6	470 ± 87	49 ± 8	363 ± 70	20 ± 4	529 ± 23	359 ± 76	2,289 ± 579#	126 ± 15
6	WT	6	18 ± 5	4,268 ± 1,148	476 ± 40	824 ± 72	2,921 ± 241	167 ± 16	2,323 ± 136	315 ± 29
	A1-KO	9	28 ± 16	538 ± 83**	550 ± 121	209 ± 26#	6,047 ± 385#	725 ± 104#	3,380 ± 121#	304 ± 55

^ap.i., postinfection.

^bA₁-KO, C57BL/6-congenic A₁-adenosine receptor-knockout mice; WT, wild-type C57BL/6 mice.

^c**, P < 0.005; #, P < 0.001 versus values for WT mice at the same time point (by ANOVA).