TABLE 3.
Treatment of C57BL/6 mice with the A1-AdoR antagonist DPCPX significantly altered bronchoalveolar lavage fluid cytokine responses to influenza virus at 6 days p.i.a
| Mice | No. of mice | Concn (pg/ml) of: |
|||
|---|---|---|---|---|---|
| IFN-γ | IL-6 | IL-10 | KC | ||
| Untreated | 4 | 5,560 ± 1,277 | 476 ± 40 | 936 ± 16 | 167 ± 16 |
| DPCPX treated | 4 | 1,487 ± 648* | 450 ± 122 | 139 ± 26# | 127 ± 28 |
a
DPCPX treatment was 1 mg i.p. 8-cyclopentyl-1,3-dipropylxanthine/kg daily in 100 μl saline. Data are means ± SEM (to the nearest significant figure). *, P < 0.05; #, P < 0.001 versus untreated mice (by ANOVA).