TABLE 2.

T_CD4⁺ poxvirus-specific epitopes

Peptide hit	Reactivitya	% Conservation of:			Time of expression	MHC class
		Epitope (differing residue[s])	Flanking regionb	Parent protein
ECTV > VACV
A20R230–244	ECTV and VACV	100	100	97	Early	II
F15L41–56	ECTV and VACV	100	100	99	Late	II
VACV > ECTV
I1L7–21	ECTV and VACV	93.3 (V9→I9)	100	99	Late	II
I1L18–33	ECTV and VACV	100	100	99	Late	II
L4R173–187	ECTV and VACV	100	100	99	Late	II
A24R399–413	VACV only	100	100	99	Early	II
A28L7–21	VACV only	100	100	99	Late	II
D8L235–249	VACV only	86.7 (A244→V244, A249→V249)	100	95	Late	II
ECTV ≈ VACV
A18R46–60	ECTV and VACV	93.3 (A54→S54)	100	97	Early	II
E9L176–190	ECTV and VACV	100	100	98	Early	II
J4R75–89	ECTV and VACV	100	100	99	Early	II
E1L114–128	ECTV and VACV	100	100	99	Late	II
D13L483–497	ECTV and VACV	100	100	99	Late	II
H3L269–283	ECTV and VACV	100	100	96	Late	II

^aStimulation index (SI) of >2.

^bIncludes 5 amino acid residues upstream and downstream from the epitope.