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. 2014 Sep;88(17):10134–10145. doi: 10.1128/JVI.00647-14

FIG 2.

FIG 2

Strength and diversity of the CD8+ T cell response. (A) CD4+ T cell count and plasma viral load dependent on the strength of the CD8+ T cell response. The gray-shaded areas indicate the minimum and maximum of all calculated values with the corresponding strength (Ψ); the solid line denotes the mean. The horizontally shaded areas indicate the CD4+ T cell count and plasma viral load, as measured for HIV progressors (light gray) and nonprogressors (dark gray) (Table 2). (B) Relationship between the functional diversity of the CD8+ T cell response measured by the Simpson index (D) for the CD4+ T cell count and plasma viral load. All possible combinations of three different Ψ values, 0.9, 1.8, and 2.4, were analyzed separately. Lines denote the mean CD4+ T cell count and plasma viral load, while shaded areas indicate the minimum and maximum of all calculated values with the corresponding diversity index, D.