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Anti-SIV antibody responses postvaccination. (A) Levels of binding antibody against vaccine immunogen SIVmac239 Env postvaccination. (B) Avidity index for full-length Env captured from Triton X-100-disrupted VLPs SIVmac239 or SIVE660 elicited Env-specific IgG at 2 weeks after a second MVA boost. (C) Neutralization titers to tier 1 (SIVE660.11) and tier 2 (SIVE660/CR5-PK-2A5) pseudoviruses. Titers were determined at 2 weeks after a second MVA boost. D, DNA vaccine; M, MVA vaccine.
