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Summary of Vif2 and Vif1 interactions with human A3F and A3G (A) and alignment of the N-terminal 60 amino acids of HIV-2 Vif and SIVsm strain pbj14 Vif (B). Red letters, amino acids critical for specifically inducing the degradation of A3F; green letter G, G48, which is critical for inducing the degradation of A3G; blue letters, a multiple-alanine mutant (W49, A50, W51>ASA) that was defective in inducing degradation of A3H-hapII.
