TABLE 1.
Description of acute controllers (n = 10)a
| Participant | HLAs | eDPIb (pVLc) |
|
|---|---|---|---|
| Initial | Follow-up | ||
| AC01 | A*01:01/A*31:01; B*37:01/B*51:09; C*01:02/C*06:02 | 33 (25,000) | 383 (50) |
| AC02 | A*02:01/A*32:01; B*35/B*44; C*04:01/C*05 | 72 (15,200) | 469 (774) |
| AC03 | A*02:01/A*24:01; B*15:01/B*41:01; C*03/C*17 | 86 (1,490) | |
| AC04 | A*02:01/A*24:02; B*27:05/B*35:12; C*01:02/C*01:02 | 72 (1,140) | 251 (50) |
| AC05 | A*24:02/A*31:01; B*39:01/B*52:01; C*07:02/C*12:02 | 71 (7,160) | 587 (250) |
| AC06 | A*01:01/A*02:01; B*44:02/B*57:01; C*05/C*06:02 | 135 (440) | |
| AC07 | A*25:01/A*68:01; B*18:01/B*57:01; C*06:02/C*12:03 | 98 (23,900) | 204 (1,720) |
| AC08 | A*02:01/A*31:01; B*08:01/B*44:02; C*05/C*07 | 102 (572) | |
| AC09 | A*01:01/A*68:02; B*08:01/B*44:02; C*05/C*07 | 52 (45,700) | 268 (110) |
| AC10 | A*01:01/A*01:01; B*15:17/B*49:01; C*07:01/C*12:03 | 59 (22,200) | |
Abbreviations: HLA, human leukocyte antigen; eDPI, estimated number of days postinfection; pVL, plasma viral load at baseline.
Median (IQR) eDPI for AC (n = 10) at baseline, 72 (57 to 99). Median (IQR) eDPI for all AP (n = 50) at baseline, 56 (39 to 75) (P = 0.07). Median (IQR) eDPI for AP > 40 eDPI (n = 37) at baseline, 72 (53 to 88) (P = 0.4). P values represent Mann-Whitney comparisons to AC cohort.
Median (IQR) pVL in numbers of HIV RNA copies per milliliter for AC (n = 10) at baseline, 11,180 (998 to 24,175). Median (IQR) pVL for all AP (n = 50) at baseline, 337,500 (35,925 to 750,100) (P < 0.001). Median (IQR) pVL for AP > 40 eDPI (n = 37) at baseline, 186,000 (22,350 to 750,005) (P < 0.001). P values represent Mann-Whitney comparisons to AC cohort.