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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Psychoneuroendocrinology. 2014 May 29;48:29–40. doi: 10.1016/j.psyneuen.2014.05.017

Table 3.

Role of NR3C1 promoter methylation in associations between MSDP and evolution of infant baseline and AUC cortisol over the first month of life (N=45).

Predictor variables Model 11
Model 22
Model 33
β SE p β SE p β SE P
Baseline Cortisol
Intercept .559 .403 .167 .331 .410 .421 .396 .414 .340
 Time since feeding (min)4 −.164 .068 .017 −.169 .068 .013 −.161 .068 .019
 GA at birth (weeks)5 −.012 .051 .808 −.034 .053 .515 −.039 .053 .463
 Caffeine use6 .396 .150 .009 .235 .148 .114 .302 .158 <.001
 Infant age (hours)4 −.155 .044 <.001 −.160 .044 <.001 −.158 .044 <.001
 MSDP −.223 .123 .071 - - - −.155 .132 .241
 NR3C1 methylation CpG 3 - - - .105 .046 .024 .089 .048 .064
 NR3C1 methylation CpG 4 - - - .008 .022 .731 .002 .023 .933
AUC Cortisol
 Intercept 4.104 .379 <.001 3.672 .389 <.001 3.951 .392 <.001
 Time since feeding (min)4 .149 .063 .019 .137 .064 .035 .149 .063 .020
 GA at birth (weeks)5 −.094 .045 .036 −.078 .046 .090 −.102 .045 .026
 Alcohol use7 .470 .347 .178 .351 .353 .321 .494 .349 .158
 Baseline cortisol (linear)4 .644 .083 <.001 .656 .085 <.001 .637 .084 <.001
 Baseline cortisol (quadratic)4 .191 .042 <.001 .205 .044 <.001 .194 .043 <.001
 Infant age (hours)4 −.143 .042 <.001 −.143 .043 <.001 −.147 .042 <.001
 MSDP −.376 .106 <.001 - - - −.364 .117 .002
 NR3C1 methylation CpG 3 - - - .085 .048 .079 .049 .049 .318
 NR3C1 methylation CpG 4 - - - .008 .022 .698 −.010 .022 .655
1

Model with MSDP, but not NR3C1 methylation.

2

Model with NR3C1 methylation but not MSDP.

3

Model with NR3C1 methylation and MSDP.

4

Natural log transformed.

5

Centered at the mean.

6

0:≤200 mg/day, 1:>200 mg/day.

7

0:≤1 drink per week, 1:>1 drink per week.