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. Author manuscript; available in PMC: 2014 Aug 18.

Published in final edited form as: J Clin Immunol. 2013 Mar 20;33(5):991–1001. doi: 10.1007/s10875-013-9882-5

PBMC from normal donors (Nm) and IFN-γR deficient patients were stimulated with IFN-γ (400 IU/ml) or IFN-α (1,000 IU/ml) for 3 h and assayed for the expression of target genes (a) CXCL9, CXCL10, IRF-1 and (b) MX1, ISG15. *p<0.05 vs. the response observed in healthy controls; (c) Levels of CXCL10 protein were assayed in the 20 h culture supernatants. Results are mean ± SD of five independent experiments.

PBMC from normal donors (Nm) and IFN-γR deficient patients were stimulated with IFN-γ (400 IU/ml) or IFN-α (1,000 IU/ml) for 3 h and assayed for the expression of target genes (a) CXCL9, CXCL10, IRF-1 and (b) MX1, ISG15. *p<0.05 vs. the response observed in healthy controls; (c) Levels of CXCL10 protein were assayed in the 20 h culture supernatants. Results are mean ± SD of five independent experiments.