Table 1.
Demographic and Clinical Characteristic of Subjects with Normal and Decreased Thyroid Function
| Normal N = 1450 |
Subclinical Hypothyroidism N = 141 |
Hypothyroidism N = 313 * |
p-value | ||
|---|---|---|---|---|---|
| Cognition, n (%) | 0.86 | ||||
| Normal | 1213 (83.66%) | 116 (82.27%) | 259 (82.75%) | ||
| MCI | 237 (16.34%) | 25 (17.73%) | 54 (17.25%) | ||
| Age, median (25th–75th) | 80.03 (75.10 – 83.81) | 81.67 (77.37 – 84.50) | 81.20 (76.69 – 85.01) | < 0.0001φ | |
| Education, median (25th–75th) | 13 (12 – 16) | 13 (12 – 16) | 13 (12 – 16) | 0.61 | |
| BMI | 27.16 (24.38 – 30.22) | 27.16 (24.52 – 29.83) | 27.16 (24.23 – 30.30) | 0.98 | |
| ApoE ε4, n (%) | 0.30 | ||||
| No | 1079 (77.18%) | 107 (79.26%) | 222 (73.51%) | ||
| Yes | 319 (22.82%) | 28 (20.74%) | 80 (29.49%) | ||
| Gender, n (%) | <0.0001ψ | ||||
| Female | 636 (43.86%) | 70 (49.65%) | 220 (70.29%) | ||
| Male | 814 (56.14%) | 71 (50.35%) | 93 (29.71%) | ||
| Depression, n (%) | 0.62 | ||||
| No | 1259 (90.71%) | 124 (93.23%) | 279 (90.58%) | ||
| Yes | 129 (9.29%) | 9 (6.77%) | 29 (9.42%) | ||
| Diabetes | 0.47 | ||||
| No | 1185 (81.72%) | 121 (85.82%) | 255 (81.47%) | ||
| Yes | 265 (18.28%) | 20 (14.18%) | 58 (18.53%) | ||
| Hypertension | 0.79 | ||||
| No | 305 (21.03%) | 27 (19.15%) | 62 (19.81%) | ||
| Yes | 1145 (78.97%) | 114 (80.85%) | 251 (80.19%) | ||
| Stroke | 0.73 | ||||
| No | 1287 (88.76%) | 122 (86.52%) | 277 (55.50%) | ||
| Yes | 163 (11.24%) | 19 (13.48%) | 36 (11.50%) | ||
| Ever Smoker | 0.02¥ | ||||
| No | 710 (49.00%) | 77 (54.61%) | 179 (57.19%) | ||
| Yes | 739 (51.00%) | 64 (45.39%) | 134 (42.81%) | ||
| CAD | 0.38 | ||||
| No | 846 (58.34%) | 75 (53.19%) | 188 (60.06%) | ||
| Yes | 604 (41.66%) | 66 (46.81%) | 125 (39.94%) | ||
| Memory z-score, median (25th–75th) | −0.02 (−0.72, 0.71) | 0.07 (−0.77, 0.74) | 0.13(−0.68, 0.83) | 0.16 | |
| Attention z-score, median (25th–75th) | 0.12 (−0.60, 0.69) | 0.10 (−0.64, 0.66) | 0.17 (−0.55, 0.72) | 0.64 | |
| Visual Spatial z-score, median (25th–75th) | 0.05 (−0.62, 0.67) | −0.08 (−0.91, 0.66) | 0.18 (−0.66, 0.72) | 0.43 | |
| Language z-score, median (25th–75th) | 0.07 (−0.60, 0.66) | 0.06 (−0.49, 0.66) | 0.10 (−0.47, 0.72) | 0.69 | |
*
302 participants with clinical hypothyroidism were on thyroid replacement therapy
Φ
Normal vs Subclinical Hypothyroidism: p= 0.003, Normal vs Hypothyroidism: p= 0.73
Ψ
Normal vs Subclinical Hypothyroidism: p= 0.19, Normal vs Hypothyroidism: p= 0.73
¥
Normal vs Subclinical Hypothyroidism: p= 0.22, Normal vs Hypothyroidism: p=0.73
IQR: interquartile range