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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: JAMA Neurol. 2014 Feb;71(2):201–207. doi: 10.1001/jamaneurol.2013.5402

Table 2.

Association of Clinical and Subclinical Hypothyroidism with MCI

Group Thyroid groups P for
trend
Normal
Thyroid
function		 Subclinical
Hypothyroidism		 Clinical
Hypothyroidism
Total sample; n (%) 1450 (76.2%) 141 (7.4%) 313 (16.4%)
Model 1; OR (95% CI)* 1.00 (Reference) 1.03 (0.65, 1.65) 1.09 (0.77, 1.53) 0.89
Model 2; OR (95% CI) ** 1.00 (Reference) 0.88 (0.38, 2.03) 0.99 (0.66, 1.48) 0.96
Men; n (%) 814 (83.2%) 71 (7.3%) 93 (9.5%)
Model 1; OR (95% CI)* 1.00 (Reference) 1.28 (0.71, 2.31) 0.93 (0.53, 1.64) 0.68
Model 2; OR (95% CI)** 1.00 (Reference) 1.29 (0.68, 2.44) 1.02 (0.57, 1.82) 0.73
Women; n, (%) 636 (68.7%) 70 (7.6%) 220 (23.7%)
Model 1; OR (95% CI)* 1.00 (Reference) 0.76 (0.35, 1.65) 1.17 (0.76, 1.80) 0.55
Model 2; OR (95% CI)** 1.00 (Reference) 0.86 (0.37, 2.02) 1.04 (0.66, 1.66) 0.92
APOE ε4 −ve; n (%) 1079 (76.6%) 107 (7.6%) 222 (15.8%)
Model 1; OR (95% CI)* 1.00 (Reference) 1.10 (0.64, 1.89) 0.94 (0.61, 1.44) 0.88
Model 2; OR (95% CI)** 1.00 (Reference) 1.15 (0.66, 2.01) 0.87 (0.55, 1.37) 0.71
APOE ε4 +ve; n (%) 319 (74.7%) 28 (6.6%) 80 (18.7%)
Model 1; OR (95% CI)* 1.00 (Reference) 0.84 (0.30, 2.32) 1.35 (0.74, 2.45) 0.56
Model 2; OR (95% CI)** 1.00 (Reference) 0.88 (0.28, 2.78) 1.47 (0.79, 2.76) 0.45
*

Logistic regression models.

*

Model 1 is adjusted for age at visit, sex and education.

**

Model 2 is adjusted for age at visit, years of education, any APOE ε4 allele, Beck Depression Inventory depression, diabetes, hypertension, stroke, body mass index, coronary artery disease, and smoking.

P-value for interaction of sex with hypothyroidism = 0.45

P-value for interaction of APOE ε4 with hypothyroidism = 0.30