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. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: Dev Biol. 2014 Jun 19;392(2):141–152. doi: 10.1016/j.ydbio.2014.06.009

Figure 8. A model of CDH-4 genetic interaction with UNC-40/DCC, PTP-3/LAR, and MIG-21 that is consistent with data described in this work.

Figure 8

A) CDH-4 acts non-autonomously with PTP-3/LAR and MIG-21 in parallel to UNC-40/DCC in directing posterior QL migration. Grouping of molecules does not imply physical interaction in this model, rather action in the same genetic pathway. The non-autonomous cellular source of CDH-4 is unknown (?). B) CDH-4 acts in both the PTP-3/LAR and UNC-40/DCC pathways in QR in mutual inhibition, allowing anterior QR migration. The QR-specific factor that mediates UNC-40/DCC function with PTP-3/LAR in QR but not QL is unknown (?).