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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: Sci Transl Med. 2014 May 14;6(236):236ra64. doi: 10.1126/scitranslmed.3008523

Figure 1. Loss of all PHD isoforms is required for radioprotection.

Figure 1

(A) Western blots from purified epithelial cells of the indicated genotypes and tissues. The wildtype (WT) lane is from the PHD1/2/3 fl/fl animal without Villin-Cre. The various floxed PHD animals were of a mixed C57/BL6-FVB genetic background. (B) Kaplan-Meier analysis of GI-PHD1/2/3 knockout mice and controls after 18Gy total abdominal irradiation (TAI). n=8 per genotype and p=0.005 by log-rank test. (C) Kaplan-Meier analysis of GI-PHD1/2/3 knockout mice and controls after 14Gy total body irradiation (TBI). n=9 per genotype and p=0.02 by log rank test.