Table III.
Mice | Rats | Dogs | |
---|---|---|---|
Bioavailability (%) | 15.5±3.6a | 28.5±0.2b | 56.8 ± 7.3c |
Lymphatic transport (%)d | 2.0 ±0.5 | 6.9 ±0.3b | 28.0±3.9c |
Proportion transported via lymph (%) | 12.9 | 24.2 | 49 |
Co-efficient of variation shown for mouse bioavailability data
Significantly greater than the same parameter in mice (p<0.05)
Significantly greater than the same parameter in mice and rats (p<0.05)
Studies were conducted in conscious animals administered halofantrine via the oral route, except for the lymphatic transport studies in mice and rats which were conducted in anaesthetised animals administered halofantrine via intraduodenal infusion. Lymphatic transport of halofantrine was similar in conscious and anaesthetised rats (Supplementary Material Fig. S1) providing support for the use of data in anaesthetised rats and mice in the current comparison.