Table 2.

Single Nucleotide Polymorphisms in HTR4 and ADAM19 that were statistically significant (P<1.58×10⁻⁴) for association with either FEV1 or FEV1/FVC in the unconditional analysis

Phenotype	Target	SNP position	dbSNP	Allele1	Allele2	Freq1	Unconditional Analysis *			DirectionFHS, ARIC, CHS**	Conditional Analysis P value
							Beta	SE	P value
FEV1	HTR4	chr5:147822546	rs11168048	t	c	0.6011	−0.0309	0.0140	5.47×10	−−−	Sentinel-NA
		chr5:147827466	rs4597955	a	g	0.5670	0.0165	0.0133	3.50×10−5	+++	0.1630
		chr5:147824585	rs7735184	t	g	0.3962	0.0251	0.0139	4.11×10−5	−++	0.9672
		chr5:147821023	rs6860089	a	t	0.3864	0.0317	0.0138	4.16×10−5	−++	0.9888
		chr5:147821021	rs6860087	a	t	0.3914	0.0313	0.0138	4.45×10−5	−++	0.9911
		chr5:147820305	rs10041517	t	c	0.3293	0.0307	0.0141	4.96×10−5	−++	0.7584
		chr5:147828839	rs1989153	t	c	0.6767	−0.0300	0.0142	6.59×10−5	−−−	0.6981
		chr5:147819037	rs10463406	t	c	0.3953	0.0235	0.0139	8.05×10−5	−++	0.8637
		chr5:147829952	rs3995091	a	g	0.4292	0.0306	0.0135	8.66×10−5	+++	0.8748
		chr5:147819730	rs10075211	t	c	0.5624	−0.0285	0.0135	1.13×10−4	−−−	0.895
		chr5:147836585	rs7715901	a	g	0.6198	−0.0253	0.0140	1.22×10−4	+−−	0.9497
		chr5:147836526	rs7733088	a	g	0.3792	0.0273	0.0140	1.27×10−4	−++	0.9234
FEV1/FVC	HTR4	chr5:147822546	rs11168048	t	c	0.6025	−0.0093	0.0022	5.17×10−8	−−−	Sentinel-NA
		chr5:147828839	rs1989153	t	c	0.6717	−0.0090	0.0022	1.75×10−7	−−−	0.2784
		chr5:147836585	rs7715901	a	g	0.6216	−0.0090	0.0021	2.56×10−7	−−−	0.5276
		chr5:147824585	rs7735184	t	g	0.3942	0.0081	0.0022	8.38×10−7	+++	0.8955
		chr5:147819037	rs10463406	t	c	0.3936	0.0079	0.0022	9.50×10−7	+++	0.8758
		chr5:147836526	rs7733088	a	g	0.3772	0.0091	0.0021	9.51×10−7	+++	0.6665
		chr5:147821021	rs6860087	a	t	0.3891	0.0086	0.0021	1.59×10−6	+++	0.9395
		chr5:147826900	rs6889822	a	g	0.6306	−0.0088	0.0022	2.02×10−6	−−−	0.8349
		chr5:147821023	rs6860089	a	t	0.3840	0.0083	0.0021	2.04×10−6	+++	0.9517
		chr5:147826008	rs3995090	a	c	0.6030	−0.0080	0.0022	2.10×10−6	−−−	0.9947
		chr5:147826596	rs11742110	t	c	0.6055	−0.0078	0.0022	3.02×10−6	−−−	0.9425
		chr5:147829952	rs3995091	a	g	0.4278	0.0071	0.0021	4.44×10−6	+++	0.8141
		chr5:147835457	rs11168049	t	c	0.6187	−0.0076	0.0022	6.74×10−6	−−−	0.997
		chr5:147817073	rs12374521	t	c	0.5391	−0.0063	0.0021	1.58×10−5	−−−	0.6832
		chr5:147829828	rs1988818	t	c	0.4307	0.0064	0.0021	2.09×10−5	+++	0.9314
		chr5:147819730	rs10075211	t	c	0.5643	−0.0063	0.0021	2.09×10−5	−−−	0.9415
		chr5:147831463	rs6887366	a	t	0.5677	−0.0067	0.0021	2.41×10−5	−−−	0.8996
		chr5:147829724	rs1988819	t	c	0.4346	0.0064	0.0021	2.73×10−5	+++	0.8897
		chr5:147827981	rs1985524	c	g	0.4328	0.0065	0.0021	3.02×10−5	+++	0.8684
		chr5:147827466	rs4597955	a	g	0.5653	0.0042	0.0021	3.36×10−5	+++	0.2972
		chr5:147836715	rs7733410	a	g	0.4254	0.0069	0.0021	6.42×10−5	+++	0.9967
		chr5:147820305	rs10041517	t	c	0.3303	0.0065	0.0022	7.00×10−5	−++	0.7765
		chr5:147816802	rs13156542	t	c	0.5538	−0.0059	0.0020	7.73×10−5	−−−	0.7984
		chr5:147835163	rs10037493	t	c	0.4234	0.0056	0.0021	1.25×10−4	+++	0.9289
ADAM19		chr5:156849167	rs13155908	a	g	0.8769	−0.0104	0.0029	6.56×10−6	−−−	1.56×10−4
		chr5:156849189	rs10058865	a	c	0.1108	0.0109	0.0031	1.41×10−5	+++	3.84×10−4
		chr5:156866145	rs13190258	a	c	0.8802	−0.0097	0.0030	4.36×10−5	−−−	7.62×10−4
		chr5:156877473	rs59327154	a	g	0.8308	−0.0093	0.0027	4.55×10−5	−−−	9.26×10−4
		chr5:156851428	rs2287749	t	c	0.1220	0.0097	0.0030	5.20×10−5	+++	7.37×10−4
		chr5:156909971	rs11748149	a	g	0.0980	0.0121	0.0031	5.55×10−5	+++	7.79×10−4
		chr5:156889456	rs72811319	a	g	0.1030	0.0123	0.0031	7.36×10−5	+++	8.96×10−4
		chr5:156903456	rs11739504	a	c	0.9039	−0.0122	0.0032	8.71×10−5	−−−	1.03×10−3
		chr5:156846458	rs34458213	a	t	0.8831	−0.0091	0.0030	8.93×10−5	−−−	1.18×10−3
		chr5:156880634	rs72811309	a	g	0.1020	0.0124	0.0031	9.21×10−5	+++	1.08×10−3
		chr5:156880625	rs72811307	t	c	0.8980	−0.0122	0.0031	1.03×10−4	−−−	1.14×10−3
		chr5:156890868	rs11134799	t	c	0.8969	−0.0121	0.0031	1.07×10−4	−−−	1.24×10−3
		chr5:156880896	rs72811310	t	g	0.8974	−0.0118	0.0031	1.29×10−4	−−−	1.33×10−3
		chr5:156839688	rs11466816	t	g	0.1126	0.0090	0.0031	1.36×10−4	+++	1.48×10−3

^*Unconditional analysis includes only the SNP listed. For FEV1 the beta value is the change in liters per copy of allele 1. For FEV1/FVC the beta value is the change in FEV1/FVC scaled as a proportion (range 0–1) per copy of allele 1. Conditional analysis model includes the SNP listed plus the sentinel SNP for the specific gene target (HTR4 rs11168048, ADAM19 rs1422795) and the P value given is for the beta value for the SNP listed.

ADAM19 rs1422795 gave P = 0.02 in the unconditional analysis and is thus not listed in this table.

^**Direction refers to the sign of the beta coefficient by cohort in the following order: FHS (Framingham Health Study), ARIC (Atherosclerosis Risk in Communities), CHS (Cardiovascular Health Study). A “+” indicates a positive beta coefficient and a “−” indicates a negative beta coefficient