Table 1.

The means and SEMs for the mice in the elevated plus maze. The Tg2576 mice that received OL-1 spent a greater amount of time in the closed arms compared to the Tg2576 mice that received RA. The Tg2576 mice that received OL-1 entered the open arms more frequently and made more arm changes than the mice that received random antisense. The wild type mice that received RA spent a greater amount percentage of time in the closed arms and changed arms more frequently than the Tg2576 mice that received RA. There were no differences on any measure between the wild type mice and the Tg2576 mice that received OL-1, n = 8 to 10 per group.

Group	% Closed	Entries Open	Time Open (sec)	Change Freq
Tg2576 RA	31 ± 19 +	4.0 ± 0.85	196.33 + 46.60	7.5 ± 2.13 +
Tg2576 OL-1	52 ± 12	14.00 ± 3.04 **	116.29 + 25.27	29.71 ± 5.29 **
Wild Type RA	79 ± 5	9.63 ± 1.79	41.38 + 9.77	23.25 ± 4.14

⁺Indicates P<0.05 of the same treatment in the opposite strain.

^**Indicates P<0.01 compared to the RA given to the same strain.