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. Author manuscript; available in PMC: 2015 Aug 14.
Published in final edited form as: Chem Biol. 2014 Aug 14;21(8):967–976. doi: 10.1016/j.chembiol.2014.06.008

Figure 4.

Figure 4

Simultaneous inhibition of the GCase–ERdj3 interaction and enhancement of the chaperoning activity of calnexin exhibits synergy in L444P GCase fibroblasts. (A) Silencing ERdj3 enhanced the interaction between L444P GCase and calnexin in fibroblasts. (B) Silencing ERdj3 did not affect the interaction between WT GCase and calnexin in fibroblasts. IP, immunoprecipitation; IB, immunoblot. (C) Co-application of diltiazem and ERdj3 siRNA synergistically enhanced L444P GCase lysosomal activity. The data in (C) are reported as mean ± SD (n = 8). DTZ, diltiazem. See also Figure S5.