Table 1.

IC₅₀ values [μM] of cisplatin and conjugates 1 and 2, as determined in proliferation assays for different tumor cell lines with incubation times of 24 h and 72 h.

	HCT 116[a]		OVCAR3[b]		MDA-MB-231[c]		1483 HNSCC[d]
	24 h	72 h	24 h	72 h	24 h	72 h	24 h	72 h
cisplatin	22.3	12.0	10.7	2.07	159.8	20.0	8.6	2.0
1	2.5	1.1	7.7	2.2	20.1	1.65	3.5	0.69
2	0.22	0.065	1.5	0.13	1.05	0.05	0.54	0.045

^[a]Colorectal carcinoma, no COX-2 expression.

^[b]Ovarian adenocarcinoma, COX-1 expression.

^[c]Breast adenocarcinoma, COX-2 expression.

^[d]Head and neck squamous cell carcinoma, high COX-2 expression.