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. 2014 Jul 28;111(32):11876–11881. doi: 10.1073/pnas.1406000111

Fig. 1.

Fig. 1.

(A and B) VMH PREP and glucose metabolism. Light microscopic photograph of representative coronal sections after in situ hybridization (A) or LacZ staining (B). (C) Results from the GTT in Prepgt/gt and WT. The area AUC analysis showed a significant glucose intolerance in Prepgt/gt mice compared with the WT controls (n = 10 for each group). (D) Circulating insulin levels in WT (n = 6) and Prepgt/gt mice (n = 4) during the GTT. (E) Glucagon levels during GTT (WT: n = 6; Prepgt/gt: n = 4). (F) The results of PTT in Prepgt/gt and WT mice (n = 4/group). (G and H) Increased G6pase and Pepck mRNA expression in the Prepgt/gt mice (n = 6) compared with their WT controls (n = 6). All data represent the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001. [Scale bar in A (also applies to B), 2 mm.] ARC, arcuate nucleus; LH, lateral hypothalamus; 3v, third ventricle; VMH, ventromedial nucleus.