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. 2014 Jul 29;111(32):11786–11791. doi: 10.1073/pnas.1323557111

Fig. 2.

Fig. 2.

Zip10-deficient mature B cells have a shortened lifespan. (A) Resident IgDhiIgMlo FO B-cell population in the spleen from Rag-1 KO mice transferred purified splenic B cells. Bar charts representing the relative cell numbers 10 d posttransfer (n = 3 for each). Data represent the mean ± SD (*P < 0.05, **P < 0.01). (B) BrdU incorporation in B-cell subsets in the BM and spleen. IMM: CD45RloIgM+; recirculating: CD45RhiIgM+; TR: CD45R+AA4.1+; mature: CD45R+AA4.1−. (C) BrdU incorporation in mature (CD45R+AA4.1−) B cells from mixed BM chimeras. (D) Lifespan of peripheral B cells. The relative percentage of CD45R+BrdU+ cells in the blood is shown (8 wk, n = 4 for Ctrl, n = 9 for Ii-Cre-cKO). Data represent the mean ± SD (***P < 0.001).