Fig. 2.
IL-10 is required for H. pylori-induced protection against allergic asthma. (A and B) IL-10 secretion by murine bone-marrow-derived DCs of the indicated genotypes and human monocyte-derived DCs from six healthy volunteers after exposure to H. pylori extract. One representative experiment of three is shown in A, and pooled data for all six donors is shown in B. (C–F) Mice were treated as described in Fig. 1 or were neonatally infected with H. pylori; the indicated groups received 2 doses of anti-IL-10R antibody during ovalbumin challenge. (G–J) CD11c-Cre.IL-10fl/fl mice and their IL-10fl/fl littermates were either neonatally infected or received H. pylori extract before being subjected to ovalbumin sensitization and challenge as described in Fig. 1. Total cells (C and G) and eosinophils (D and H) contained in 1 mL of BALF. Tissue inflammation (E and I) and goblet cell metaplasia (F and J).