TABLE I.
Demographics of 57 Patients Who Underwent Metastasectomy or Repeat Resection for Metastatic Adrenocortical Carcinoma
| Feature | Median (range) |
|---|---|
| Age at diagnosis | 40 (6–72) |
| Sex, M/F | 21/36 |
|
| |
| No. (%) | |
|
| |
| Lee staging classification at initial presentation | |
| II | 10 (17) |
| III | 13 (23) |
| IV | 25 (44) |
| Unknown | 9 (16) |
| Hormonal status at initial presentation | |
| Non-functional | 19 (33) |
| Functional | 35 (61) |
| Unknown | 3 (5) |
| Hypercortisolism | 23 (66) |
| Hyperaldosteronism | 5 (14) |
| Virilization | 4 (11) |
| Feminization | 3 (9) |
| Side of primary tumor | |
| Right | 30 (53) |
| Left | 27 (47) |
| Right-sided primaries with 1st recurrence to liver | 16 (53) |
| Left-sided primaries with 1st recurrence to liver | 9 (33) |
| Disease status after resection of primary tumor | |
| NED | 45 (79) |
| Not NED | 10 (18) |
| Unknown | 2 (3) |
|
| |
| Sites and resections of distant metastases | |
| Total metastasectomies | 116 |
| Total liver resections | 23 |
| Total lung resections | 48 |
| Total abdominal resections (other than hepatic and primary) | 22 |
| Other sites resected | 23 |
|
| |
| Systemic therapy | Total/mitotane |
|
| |
| Neoadjuvant Chemotherapy | 6 (11%)/6 (11%) |
| Adjuvant chemotherapy | 34 (60%)/25 (44%) |