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. 2014 Jul 16;57(15):6729–6738. doi: 10.1021/jm5007885

Table 1. Corrector Activities of Amide-Varied Constrained Bithiazoles 7a/8a and 9a–f/10a–f Relative to Bithiazole corr4a.

corr4a:^a V_max = 475 μM/s, IC₅₀ = 6.0 μM
	9a–f; n = 1			10a–f; n = 2
compound	V_max (μM/s)	IC₅₀ (μM)	compound	V_max (μM/s)	IC₅₀ (μM)
7a	351	11.0	8a	592	9.2
9a	336	2.3	10a	512	4.1
9b	473	8.9	10b	247	4.5
9c	329	5.8	10c	717	8.7
9d	447	6.6	10d	286	2.9
9e	678	8.8	10e	481	8.3
9f	505	4.8	10f	467	6.6

^a

Corrector activity of benchmark bithiazole corr4a.