Figure 1.

Crystal structure of SHP2 in complex with compound 11c-9. (A) Overall structure of SHP2 in complex with 11c-9. The P-loop is shown in pink, the WPD-loop in blue, the Q-loop in green, the pY-loop in orange, and the β₅–β₆ loop in cyan. Compound 11c-9 is shown in stick model with unbiased F_o – F_c map contoured at 2.5σ calculated before the ligand and water molecules were added to the model. (B) Detailed interactions between compound 11c-9 and SHP2. Polar interactions or H-bonds are shown by red dashed lines.