Table 4. Selectivity of 11a-1 against a Panel of PTPs.
PTP | IC50 (μM) | PTP | IC50 (μM) |
---|---|---|---|
SHP2 | 0.20 ± 0.02 | VHR | 3.2 ± 0.1 |
LYP | 1.05 ± 0.02 | PTPμ | 3.3 ± 0.2 |
HePTP | 1.03 ± 0.08 | STEP | 4.0 ± 0.2 |
PTPH1 | 1.07 ± 0.07 | PEZ | 5.3 ± 0.2 |
SHP1 | 1.44 ± 0.04 | PTPσ | 8.6 ± 0.4 |
Ssu72 | 1.3 ± 0.2 | UBLCP1 | 9.7 ± 0.5 |
PTP1B | 2.29 ± 0.03 | laforin | 12.2 ± 2 |
LMWPTP | 2.34 ± 0.02 | CDC14A | 16 ± 4 |
VHZ | 2.3 ± 0.2 | PTPε | >20 |
PTPγ | 2.4 ± 0.4 | PTPα | >100 |
MKP5 | 2.9 ± 0.1 |