Table 2.
Volumes and Function by Cardiac Magnetic Resonance
| Control Subjects (n = 23) |
SLE (n = 27) |
CAD (n = 25) |
p Value | |
|---|---|---|---|---|
| LVED index, ml/m2 | 79 ± 23 | 71 ± 18 | 112 ± 41∗ | <0.001 |
| LVES index, ml/m2 | 33 ± 11 | 39 ± 14 | 68 ± 49∗ | <0.001 |
| Ejection fraction, % | 58 ± 7 | 56 ± 11 | 46 ± 18∗ | 0.02 |
| LV mass index, g/m2 | 44 ± 21 | 49 ± 11 | 68 ± 31∗ | 0.05 |
| Adenosine perfusion | ||||
| Abnormal | 0 (0) | 8 (30) | 22 (88) | <0.001 |
| Inducible ischemia | 0 (0) | 0 (0) | 19 (76) | <0.001 |
| Microvascular disease | 0 (0) | 8 (30) | 0 (0) | <0.001 |
| LGE, n present | 0 (0) | 11 (41)† | 20 (80)∗ | <0.01 |
| Pulse wave velocity, m/s | 4.7 ± 2.0 | 8.1 ± 3.1† | 8.7 ± 2.6∗ | <0.001 |
| CE intensity | 0.002 | |||
| Mild | 4 (17) | 3 (11) | 2 (8) | |
| Moderate | 0 (0) | 9 (33) | 8 (32) | |
| Severe | 0 (0) | 15 (66) | 15 (60) | |
| CE pattern | ||||
| Patchy/regional | 3 (13) | 3 (11)† | 19 (76)∗ | <0.001 |
| Generalized | 1 (4) | 24 (89)† | 6 (24)∗ | <0.001 |
| CNR | 3.9 ± 2.5 | 6.9 ± 2.5† | 6.8 ± 2.0∗ | <0.001 |
| Total area, mm2 | 0.8 (0.6–1.2) | 3.2 (2.6–4.0)† | 3.3 (1.9–4.5)∗ | <0.001 |
Values are mean ± SD, n (%), or median (interquartile range). One-way ANOVA and Kruskall-Wallis with post-hoc tests for the differences ∗for controls vs. coronary artery disease (CAD) patients and †for controls vs. systemic lupus erythematosus (SLE).
CE = coronary enhancement; CNR = contrast to noise ratio; LGE = late gadolinium enhancement; LV = left ventricular; LVED = left ventricular end-diastolic; LVES = left ventricular end-systolic; other abbreviations as in Table 1.