Skip to main content
. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: Clin Cancer Res. 2014 Jan 14;20(6):1566–1575. doi: 10.1158/1078-0432.CCR-13-2195

Figure 4. GANT61 is more effective than GDC-0449 in reducing cell survival and inducing apoptosis.

Figure 4

A∼B. 96-hour treatment of GDC-0449 generated limited growth inhibition (A) and apoptosis (B). Only moderate cytotoxicity was observed in NCI-H520 and NCI-H226 cells at 10 μmol/L. C∼D. 96-hour treatment of GANT61 significantly reduced cell survival (C) and induced extensive apoptosis (D) in all GLI-positive cell lines. GLI-negative NCI-H2170 was not affected by GANT61. Data were normalized to DMSO control and represent the mean ± SD of 3 independent experiments. (Two-tailed t test, *: p<0.05; **: p<0.01; ***: p<0.001)