Table 3.
Blood pressure, heart rate and blood chemistry.
| Hb vesicles | ||||
|---|---|---|---|---|
| Baseline | HbV7 | HbV10 | COHbV7 | COHbV10 |
| N | 4 | 4 | 4 | 4 |
| MAP, mmHg | 112 ± 7 | 114 ± 8 | 110 ± 8 | 109 ± 6 |
| HR, bpm | 432 ± 24 | 428 ± 25 | 430 ± 20 | 426 ± 21 |
| Hct, % | 49 ± 1 | 48 ± 2 | 48 ± 2 | 49 ± 1 |
| Hb, g/dl | 14.9 ± 0.7 | 14.7 ± 0.6 | 14.8 ± 1.0 | 14.8 ± 0.6 |
| Body weight, g | 64.3 ± 4.2 | 65.2 ± 4.1 | 65.6 ± 6.0 | 64.7 ± 5.8 |
| HbV and COHbV infusion | ||||
| 1st infusion of 10% of the animal's BV | ||||
| Hct, % | 46 ± 1 | 46 ± 2 | 45 ± 2 | 47 ± 1 |
| Total Hb, g/dl | 15.6 ± 0.8 | 15.9 ± 0.8 | 15.6 ± 0.6 | 15.8 ± 0.7 |
| COHb,% of total Hb | - - | - - | 2.0 ± 1.2† | 2.6 ± 1.6† |
| MetHb, % of total Hb | - - | - - | - - | - - |
| 2nd infusion of 10% of the animal's BV | ||||
| Hct, % | 45 ± 2 | 44 ± 2 | 44 ± 2 | 44 ± 1 |
| Hb, g/dl | 16.3 ± 0.9 | 16.9 ± 0.8 | 16.0 ± 1.2 | 16.5 ± 0.6 |
| COHb,% of total Hb | - - | - - | 3.4 ± 0.9† | 4.6 ± 1.2† |
| MetHb, % of total Hb | - - | 3.6 ± 0.5† | - - | - - |
| Blood Viscosity, cP | 4.7 ± 0.4† | 4.9 ± 0.5† | 4.8 ± 0.4† | 5.1 ± 0.4† |
| Plasma Viscosity, cP | 1.7 ± 0.2† | 1.9 ± 0.2† | 1.8 ± 0.1† | 2.0 ± 0.3† |
Absolute values for mean arterial pressure (MAP), heart rate (HR), hematocrit (Hct), Hb and body weight at baseline. The total Hb concentration, Hct, COHb and metHb levels after the 1st infusion and total Hb concentration, Hct, COHb and metHb levels and blood/plasma viscosities after the 2nd infusion are also presented.
*
measured at 160 s−1 and 37°C.
†
P<0.05 compared to baseline.