Table 2. Intensity response in key CST areas and control regions.

Absolute difference to controls (%)	PLIC left	PLIC right	Para-ventricular left	Para-ventricular right	Subcentral left	Subcentral right	frontal left	frontal rigth	occipital left	occipital right
low disability	7.2***	4.8*	2.2 n.s.	0.8 n.s.	2.7*	3.2*	−2.0 n.s.	−2.1 n.s.	1.2 n.s.	1.6 n.s.
high disability	8.7***	5.5 n.s.	6.2*	4.6 n.s.	5.7**	6.4**	0.0 n.s.	−1.6 n.s.	2.8 n.s.	−1.1 n.s.
all patients	8.7***	5.1**	4.1**	2.6 n.s.	4.1***	4.7***	−1.1 n.s.	−1.8 n.s.	2.4 n.s.	0.3 n.s.

Mean intensity inside ROIs along the CST and in ALS independent white matter regions are shown. The absolute difference of the mean in patients versus controls is referenced to the total white matter intensity spread to allow comparability to other study settings. Significances are given as * (p<0.05), ** (p<0.01), ***(P<0.001) or as not significant (n.s.). The highest response was found in the left PLIC (8.7% higher intensity in patients than in controls). The non ALS disease related white matter regions did not significantly differ between patients and controls.