Table 4. Associations between cytokine levels in plasma and behavior as determined by linear regression analyses.

Cytokine	Diet group	Anhedonia		Species-typical behavior		Anxiety				Memory
						Peaks into LB of LDB		Time spent in LB of LDB
		p	r2	p	r2	p	r2	p	r2	p	r2
IL-6	All									0.015	0.21
IL-12p70	All	0.015	0.23
	Control							0.011	0.83
	High-sucrose			0.004	0.77					0.034	0.55
	High-fat					0.030	0.42
IL-17A	All	0.057	0.14
	High-sucrose									0.034	0.55

Several associations were found between systemically circulating inflammatory markers and behavior. Statistically significant linear regressions revealed that high levels of IL-6 was related to poor memory performance, and high levels of IL-12p70 increased anxiety in the triple test, measured by increased numbers of peaks into the light box, without entering, and decreased time spent in the light box. IL-17A is associated with amount of sucrose consumption and memory. Behavior was not correlated to IL-1β, IL-10 and TNF-α, as all samples were at basal concentrations regarding these cytokines. Not shown and non-significant are: In the triple test; Time spent in center of OF, time spent on OA, risk assesment to OA, and in the FST; Latency to and time spent immobile. Italic: negative correlation. Bold: Positive correlation.