Table 1. Top Associations between SNVs and BMI-Related Traits.
Phenotype | n analyzed | Chr | SNV | position | context | nearest gene (s) | RA | AA | RAF | β | se | p-value |
BMI | 5,343 | 5 | rs955423 | 165652228 | intergenic | TENM2 | A | C | 0.610 | 0.335 | 0.066 | 3.45·10−7 |
BMI | 5,343 | 4 | rs3096490 | 110198580 | intronic | COL25A1 | G | A | 0.529 | 0.317 | 0.063 | 5.32·10−7 |
BMI | 5,343 | 5 | rs1392280 | 165608261 | intergenic | TENM2 | G | A | 0.659 | 0.332 | 0.067 | 6.90·10−7 |
BMI | 5,343 | 15 | rs1426654 | 46213776 | exonic | SLC24A5 | A | G | 0.510 | 0.325 | 0.066 | 7.54·10−7 |
BMI | 5,343 | 4 | rs794149 | 110179691 | intronic | COL25A1 | A | G | 0.521 | 0.314 | 0.064 | 8.36·10−7 |
BMI | 5,343 | 4 | rs3096483 | 110189985 | intronic | COL25A1 | T | C | 0.524 | 0.313 | 0.063 | 8.37·10−7 |
Change in BMI | 4,983 | 5 | rs10041997 | 120226210 | intergenic | PRR16,FTMT | A | G | 0.518 | 0.138 | 0.027 | 4.40·10−7 |
Change in BMI | 4,983 | 5 | rs1347155 | 171901953 | intergenic | SH3PXD2B,NEURL1B | T | C | 0.042 | 0.341 | 0.068 | 4.97·10−7 |
Change in BMI | 4,983 | 2 | rs7565158 | 213302215 | intergenic | ERBB4,MIR4776-2 | A | C | 0.495 | 0.136 | 0.027 | 6.34·10−7 |
Height | 5,344 | 15 | rs8042988 | 87213283 | intronic | ACAN | A | G | 0.621 | 0.006 | 0.001 | 3.81·10−7 |
Height | 5,344 | 14 | rs4898878 | 55462859 | intergenic | LINC00520,PELI2 | A | G | 0.709 | 0.006 | 0.001 | 9.07·10−7 |
Underweight | 4,474 | 14 | rs12882679 | 78916991 | intronic | NRXN3 | G | A | 0.687 | 0.057 | 0.012 | 9.57·10−7 |
Overweight | 3,244 | 14 | rs1475010 | 25206451 | intergenic | STXBP6,NOVA1 | C | A | 0.307 | 0.060 | 0.012 | 5.74·10−7 |
Overweight | 3,244 | 14 | rs8181969 | 25214651 | intergenic | STXBP6,NOVA1 | C | A | 0.305 | 0.059 | 0.012 | 8.49·10−7 |
AA: Alternative Allele; the allele associated with a decrease in the phenotype; BMI: Body Mass Index; Chr.: Chromosome; Overweight: BMI ≥23 kg/m2; compared to normal weight; Position: From build 36.1; RA: Risk allele; the allele associated with an increase in the phenotype; RAF: Risk Allele Frequency; SNV: Single Nucleotide Variant; se: Standard Error; Underweight: BMI <18.5 kg/m2, compared to normal weight.