Table 2.
Pregnancy and neonatal outcome of the study population according to the presence or absence of amnionitis among the cases of preterm births (36 weeks’ gestation) with histologic chorioamnionitis.
| Absence of amnionitis | Presence of amnionitis | p value | ||
|---|---|---|---|---|
| N=165 | N=125 | Unadjusted | Adjustedc | |
| 57% (165/290) | 43% (125/290) | |||
| Median gestational age at delivery, weeks (median and range) | 33.4 (19.7–36.0) | 30.6 (17.4–35.7) | <0.001 | - |
| Mean birth weight, g (mean ± SD) | 1853 ± 667 | 1541 ± 636 | <0.001 | - |
| Clinical chorioamnionitis | 4% | 17% | <0.001 | <0.05 |
| Funisitis | 27% | 78% | <0.001 | <0.001 |
| Inflammation of chorionic plate | 11% | 55% | <0.001 | <0.001 |
| Chorio-deciduitis | 93% | 98% | <0.05 | NS |
| Chorio-deciduitis, grade 2 | 10% | 50% | <0.001 | <0.001 |
| Positive amniotic fluid culturea | 22% (18/82) | 44% (31/70) | <0.01 | <0.05 |
| Intra-amniotic inflammationb | 55% (45/82) | 90% (59/66) | <0.001 | <0.005 |
| Umbilical cord plasma CRP ≥200 ng/mle | 22% (33/151) | 64% (68/106) | <0.001 | <0.001 |
| Proven early-onset neonatal sepsisd | 2% (3/146) | 7% (8/109) | 0.059 | 0.062 |
| Proven or suspected early-onset neonatal sepsisd | 11% (16/146) | 33% (36/109) | <0.001 | <0.001 |
NS, not significant.
Of 156 cases who underwent amniocentesis within 5 days of birth, AF culture results were available in 152 cases.
Of 156 cases who underwent amniocentesis within 5 days of birth, 148 patients were included in this analysis, because the test of AF MMP-8 concentration was not performed in 8 cases due to the limited amount of the remaining fluid.
Adjusted for gestational age at delivery, the cause of preterm delivery and parity (≥1) (logistic regression analysis).
Thirty-five neonates were excluded from the analysis because they died shortly after delivery as a result of extreme prematurity (n = 25) or anomaly (n = 5) or were delivered at another institution (n = 5) and thus could not be evaluated with respect to the presence or absence of neonatal complications.
Of 290 cases which met the entry for this study, 257 patients had an umbilical cord plasma CRP concentration at birth; however, 33 patients did not have an umbilical cord CRP concentration at birth because of the limited amount of the remaining plasma.