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. 2014 Aug 18;9(8):e105354. doi: 10.1371/journal.pone.0105354

Figure 3. Insulin activates insulin and IGF-1 receptors and PI3K/AKT – MEK downstream pathways.

Figure 3

(A) Expression and phosphorylation of insulin receptor by insulin in a time (0 to 60 min) and dose (0 to 1000 nM) dependent manner. (B) Expression and phosphorylation of IGF-1 receptor by insulin in a time and dose dependent manner. (C) HSD11B2 mRNA expression monitored by qRT-PCR in presence of insulin, AKT inhibitor (AKTVIII, 0.1 µM and 10 µM) or MEK inhibitor (PD098059, 1 µM).