Table 6. Comparison of biochemical changes to previously published results.
Biochemical Pathway/Name | Barnes et al., J. Dent. Res. [12] Saliva Periodontitis vs. Healthy | Current Study Saliva (Non-diabetic subjects only) Periodontitis vs. Healthy |
Purine Degradation (Link to Oxidative Stress) | Increased* | Increased |
Dipeptides (Macromolecular degradation of proteins) | Increased | Increased |
Amino Acid Metabolites (p-cresol sulfate, Bacterial) | Increased | Increased |
Carbohydrates (monosaccharides indicative of amylase activity) | Increased | Increased |
Energy Metabolites (TCA cycle, indicative of energetic stress) | Unchanged | Increased |
Uridine (DNA/RNA Degradation) | Increased | Increasing trend** |
Allantoin | Increased | Increasing trend |
ω-6 fatty acids (link to inflammation) | Increased | Increased |
Fatty Acids | Increased | Increased |
Acetylcarnitine | Increased | Increased |
Carnitine | Increased | Unchanged |
3-dehydrocarnitine | Increased | Increased |
*Increased with statistically significant differences (p≤0.05) in biochemicals from those pathways. I
**Increasing trend reflects differences (0.05<p≤0.10) in biochemicals from those pathways.