Table 6. Comparison of biochemical changes to previously published results.
| Biochemical Pathway/Name | Barnes et al., J. Dent. Res. [12] Saliva Periodontitis vs. Healthy | Current Study Saliva (Non-diabetic subjects only) Periodontitis vs. Healthy |
| Purine Degradation (Link to Oxidative Stress) | Increased* | Increased |
| Dipeptides (Macromolecular degradation of proteins) | Increased | Increased |
| Amino Acid Metabolites (p-cresol sulfate, Bacterial) | Increased | Increased |
| Carbohydrates (monosaccharides indicative of amylase activity) | Increased | Increased |
| Energy Metabolites (TCA cycle, indicative of energetic stress) | Unchanged | Increased |
| Uridine (DNA/RNA Degradation) | Increased | Increasing trend** |
| Allantoin | Increased | Increasing trend |
| ω-6 fatty acids (link to inflammation) | Increased | Increased |
| Fatty Acids | Increased | Increased |
| Acetylcarnitine | Increased | Increased |
| Carnitine | Increased | Unchanged |
| 3-dehydrocarnitine | Increased | Increased |
*Increased with statistically significant differences (p≤0.05) in biochemicals from those pathways. I
**Increasing trend reflects differences (0.05<p≤0.10) in biochemicals from those pathways.