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. 2014 Aug 18;9(8):e105216. doi: 10.1371/journal.pone.0105216

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© 2014 Xu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: The scheme of dedifferentiation (including reprogramming and differentiation) and transdifferentiation. B: A model for the gene circuit for cell development. C: The phase diagram for the gene circuit with . D: The cell fate landscape obtained from the Hamilton-Jacobi equation versus and , and the phase diagram was drawn on the intrinsic potential landscape with stable states represented by black solid lines and unstable states represented by black dash line. The red dash lines represent the dedifferentiation(reprogramming) and redifferentiation process while the yellow solid lines represents the transdifferentiation process. (, , .)

Inline graphic — A: The scheme of dedifferentiation (including reprogramming and differentiation) and transdifferentiation. B: A model for the gene circuit for cell development. C: The phase diagram for the gene circuit with . D: The cell fate landscape obtained from the Hamilton-Jacobi equation versus and , and the phase diagram was drawn on the intrinsic potential landscape with stable states represented by black solid lines and unstable states represented by black dash line. The red dash lines represent the dedifferentiation(reprogramming) and redifferentiation process while the yellow solid lines represents the transdifferentiation process. (, , .)