Table 1.
Gene Ontology* and KEGG pathway enrichment analysis of differentially expressed genes between U87MG-EGFRvIII and -vector cells
| Rank | GO ID | GO term | P value | Pathway ID | Definition | P value |
|---|---|---|---|---|---|---|
| 1 | GO:0006928 | Cell motion | <.001 | hsa03010 | Ribosome | .001 |
| 2 | GO:0043062 | Extracellular structure organization | <.001 | hsa04512 | ECM-receptor interaction | .002 |
| 3 | GO:0051674 | Localization of cell | <.001 | hsa04510 | Focal adhesion | .003 |
| 4 | GO:0048870 | Cell motility | <.001 | hsa05200 | Pathways in cancer | .003 |
| 5 | GO:0016477 | Cell migration | <.001 | hsa05322 | Systemic lupus erythematosus | .004 |
| 6 | GO:0070482 | Response to oxygen levels | <.001 | hsa04115 | p53 signaling pathway | .006 |
| 7 | GO:0010033 | Response to organic substance | <.001 | hsa04060 | Cytokine-cytokine receptor interaction | .014 |
| 8 | GO:0051270 | Regulation of cell motion | <.001 | hsa04621 | NOD-like receptor signaling pathway | .024 |
| 9 | GO:0001568 | Blood vessel development | <.001 | hsa04610 | Complement and coagulation cascades | .031 |
| 10 | GO:0001944 | Vasculature development | <.001 | hsa04710 | Circadian rhythm | .038 |
| 11 | GO:0042127 | Regulation of cell proliferation | <.001 | hsa04810 | Regulation of actin cytoskeleton | .041 |
| 12 | GO:0001525 | Angiogenesis | <.001 | hsa04520 | Adherens junction | .043 |
Abbreviation: NOD, nucleotide binding oligomerization domain; EMC, extracellular matrix; ID, identification. *GO term category, biological process (BP).