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Mutations in DNA modifiers in hematologic malignancies
| Gene | Malignancy | Mutation % | References |
|---|---|---|---|
| DNMT3A | AML | 12%–22% | [22,23,92,93] |
| MDS | 8% | ||
| MPN | 7%–15% | ||
| MDS/MPN | 4% | ||
|
| |||
| TET2 | AML | 12%–34 % | [31,94–98] |
| MDS | 20%–25% | ||
| MPN | 4%–14% | ||
| CMML | 50% | ||
|
| |||
| IDH1/2 | AML | 15%–33% | [35,99–104] |
| MDS | 3.50% | ||
| T-ALL | 2.5%–5% | ||
| T-cell lymphoma | 5%–10% | ||
T-ALL=T-cell acute lymphoblastic leukemia.
