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. 2014 Aug 8;3:417. doi: 10.1186/2193-1801-3-417

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© Terashima et al.; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Combination effects of S-1 and eribulin in an in vivo xenograft model. (a) The tumor volumes of the four groups are plotted from day 30 until day 66 after the inoculation of MDA-MB-231 cells. The data shown represent the average values (bars, SD). *P < 0.05 versus control, **P < 0.05 versus S-1 or eribulin alone. (b) Body weight loss in mice. (c) HE staining assay and IHC assays using mouse tumor samples. Tumors were collected after 7 days of treatment and the prepared tissue slides were analyzed with HE staining and IHC using anti-E-cadherin and anti-vimentin antibodies.