Table 6.
Logistic regression analysis of TNF −863 C/A and IFN-γ -1616 T/C genotypes in association to TNF and IFN-γ concentration (pg/mL) respectively in the combined study groups
| Genotypes | OR‡ (95% CI) | Pvalue |
|---|---|---|
| TNF −863 | ||
| CC | 4.04 (2.01- 8.13) | <0.001 |
| CA | 1.00 | |
| AA | 0.31 (0.11- 0.86) | 0.024 |
| IFN-γ -1616 | ||
| TT | 8.49 (4.03- 17.91) | <0.001 |
| TC | 1.00 | |
| CC | 0.81 (0.33- 1.92) | 0.002 |
‡OR represent odds ratios while CI represents confidence intervals. Lower levels of TNF (mean ± SD; 2.99 ± 1.24) and IFN-γ (4.01 ± 1.94) concentration were assigned 0 while severe malaria (SM) patients were assigned 1 in the logistic regression analysis. OR above 1 represented value associated to SM patients while less than 1 value represented to UM patients.